Shinrei Tantei Yakumo, aka Psychic Detective Yakumo, tells a story about a college student, Saitou Yakumo who is born with different eye colours. His red left eye gives him a special ability to see ghosts and spirits. He believes ghosts and spirits are bound to earth because of a certain cause, and simply eliminating that cause will let those spirits rest in peace. Being asked for help by Ozawa Haruka, they begin the investigation together.